![]() This chemical has been studied for more than 25 years. People with migraine may have more CGRP in their blood. CGRP may cause inflammation and pain in the nervous system of people who have migraine attacks.ĬGRP migraine medications are also called anti-CGRP, CGRP inhibitor and CGRP antagonist treatment. ![]() The medication blocks a protein called calcitonin gene-related peptide (CGRP). ![]() Good luck on your migraine journey.CGRP therapies are a new type of medication used to prevent and treat migraine attacks. I have read some patients begin to see the most improvement after that point. I know it stays in your system for 5.5 months so I’m trying to be patient. I am now three months post my last Aimovig injection and my side effects are slowly improving, except for the weight gain. I decided to change routes altogether and am now doing acupuncture with surprisingly good results. Some people have had luck with other CGRP meds not causing side effects for whatever reason. Switching to another CGRP might be worth a shot. Not until I found a bunch of other people online complaining about the same issues did I link it to the CGRP. I too blamed the pandemic at first, then had my thyroid and other hormones tested. I also experienced joint pain, increased anxiety, and sleep disruptions. Yes, I was on Aimovig for 2 years and experienced an 11lb weight gain that won’t budge despite eating in a caloric deficit, exercising 6 days a week, and eliminating alcohol. After almost a year and a half off of the emgality, I can still safely say it is my biggest medication regret. I can’t say that this is “the fix” but it seems to help a little. edited to add that I also had my first depressive episode while on emgality, it was really scary Right now my med combo is continuous birth control, propranolol 60, tizanidine 2, and cymbalta 60. Apparently they aren’t unheard of side effects, they’re just highly underreported. The FDA does have my medical record, myself and my doc reported these symptoms. I can say that things definitely got better after being off of it for six months. Swollen lymph nodes with no explanation- thought I had cancer for a bit. I also struggled to regulate my body temperature while on it, resulting in constant low grade fevers. I have lingering joint pain, which the doc thinks could be permanent. My hair did finally stop six months after stopping emgality. Yep! I had terrible side effects that my docs and I were able to directly link to the emgality. Thanks for any advice, guidance and insight you can provide! Also strange - I seem to be gaining weight in places I don’t normally gain weight (like my arms and back). I’m curious to know if anyone else has experienced these side effects? If so, did you switch medications? Did the new meds help? Mind sharing what you’ve been taking instead?Īlso, if any of you did gain weight on Emgality, did you lose it? I’ve been doing everything I can to keep the weight off and down - eating in a calorie deficit, tracking my macros, working out daily - and NOTHING is helping. It wasn’t until recently that I made the connection to these side effects and Emgality (I had been blaming COVID), but based on when I starting taking the drug and others who have experienced so many similar side effects, it makes total sense that the drug might be to blame. It has helped TREMENDOUSLY with my migraines, but I have experienced some serious side effects - primarily weight gain (10-15 lbs), joint/hip pain (possibly due to weight gain?), and hair loss. Hi friends! I’ve been taking Emgality for about a year and a half.
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